International Journal of Children and Adolescents
مجله بین المللی کودکان و نوجوانان
IJCA
Medical Sciences
http://ijca.iums.ac.ir
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admin
2645-6435
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jalali
1396
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gregorian
2018
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The value of serum level of S100B protein in predicting brain edema in children with diabetes ketoacidosis
پژوهشي اصیل
Original Research
<strong>Background and Objective:</strong> The S100B protein has recently been considered as an important marker for predicting severe brain damage; however, there has been very little evidence of increasing this marker in cerebral edema due to metabolic disorders such as diabetes ketoacidosis (DKA). This study was designed and performed to evaluate the prognostic role of S100B protein in predicting brain edema in children with DKA.<br>
<strong>Methods: </strong>This case-control study was performed on children aged 22 months to 13 years who suffering moderate to severe DKA that were admitted to intensive care unit. A venous blood sample was taken from the patients during the first 6 hours of admission to the intensive care units. Based on the evidences of brain edema requiring manitol infusion, the patients were divided into 2 groups including the patients with brain edema as the cases and those without this problem as the controls. The serum level of S100B protein was measured by ELISA technique in both groups.<br>
<strong>Results:</strong> The mean serum level of S100B in the groups with and without brain edema was 1.07±1.15 and 0.67±0.99, respectively with no difference (p= 0.437). Based on the multivariable linear regression modeling, the presence of brain edema was not associated with the level of S100B. According to the ROC curve analysis S100B (AUC= 0.506, P= 0.967) could not predict the occurrence of brain edema children with DKA.<br>
<strong>Conclusion:</strong> the increase in the serum level of S100B may not predict the likelihood of brain edema in children with DKA.
Diabetes ketoacidosis, S100B, Brain edema, Child
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http://ijca.iums.ac.ir/browse.php?a_code=A-10-53-1&slc_lang=en&sid=1
Amir Ahmad
Mirbolook
1003194753284600697
1003194753284600697
No
Endocrinology and Metabolism Department, Ali Asghar Children’s Hospital, Iran University of Medical Sciences
Ladan
Afsharkhas
1003194753284600698
1003194753284600698
No
Pediatric Neurology Department, Ali Asghar Children’s Hospital, Iran University of Medical Sciences
Behzad
Haghighi Aski
1003194753284600699
1003194753284600699
No
Pediatric Intensive Care Unit Department, Ali Asghar Children’s Hospital, Iran University of Medical Sciences
Masumeh
Moradkhani Zadeh
m.soroosh@scu.ac.ir
1003194753284600700
1003194753284600700
Yes
Pediatrician, Ali Asghar Children’s Hospital, Iran University of Medical Sciences
Fattaneh
Babaei
1003194753284600701
1003194753284600701
No
Pediatrician, Ali Asghar Children’s Hospital, Iran University of Medical Sciences