International Journal of Children and Adolescents
مجله بین المللی کودکان و نوجوانان
IJCA
Medical Sciences
http://ijca.iums.ac.ir
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admin
2645-6435
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jalali
1395
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gregorian
2016
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online
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fulltext
fa
Amiloride vs hydrochlorthiazide therapy in children with nephrotic syndrome: A clinical trial
دیگر
Other
پژوهشي اصیل
Original Research
<p>Background and Objective: To assess the effectiveness and safety of oral amiloride for the treatment of<br>
edema in pediatric patients with idiopathic nephrotic syndrome.<br>
Methods: A randomized trial of amiloride vs hydrochlorthiazide was done in 34 patients. The mean age was<br>
4.3±0.7 years old. After a 2 week washout of diuretic therapy, nephrotic children with edema were randomized<br>
into two groups receiving amiloride vs hydrochlorthiazide. The effect of diuretics was assessed by the amount of<br>
weight reduction and the measurement of urinary fractional excretion of sodium during the first three days of<br>
diuretic therapy. The primary end point was the decrease in body weight.<br>
Findings: Of 34 patients enrolled for this trial, 17 patients were in amiloride group and 17 patients in hydrochlorthiazide<br>
group. The mean weight loss during the first three days of diuretic therapy was 1.3±0.65 kg in<br>
amiloride group and 1.19±0.4 kg in hydrochlorthiazide group (PV=0.55). The mean of maximum urinary fractional<br>
excretion of sodium during the first three days of diuretic therapy was 2.1±0.65% in amiloride group and<br>
1.8±1% in hydrochlorthiazide group.<br>
Conclusion: There was not any difference between amiloride and hydrochlorthiazide medications in reducing<br>
weight and increasing urinary fractional excretion of sodium in children with nephrotic syndrome.</p>
Amiloride, hydrochlorthiazide, Children, Nephrotic syndrome
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http://ijca.iums.ac.ir/browse.php?a_code=A-10-1-46&slc_lang=fa&sid=1
Soheila
Mahdavinia
1003194753284600320
1003194753284600320
No
Iran University of Medical Sciences, Tehran, Iran
Hasan
Otukesh
1003194753284600321
1003194753284600321
No
Iran University of Medical Sciences, Tehran, Iran
Rozita
Hoseini
rozitahoseini@yahoo.com
1003194753284600322
1003194753284600322
Yes
Iran University of Medical Sciences, Tehran, Iran
Mehrdad
Shheikhvatan
1003194753284600323
1003194753284600323
No
Iran University of Medical Sciences, Tehran, Iran