Volume 4, Issue 1 (2-2018)
IJCA 2018, 4(1): 0-0 |
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Khalessi N, Naderi Shiran S, Sadough P, Afshar Khas L. Zinc levels of cerebro-spinal fluid in neonatal period and its relationship with seizure disorders. IJCA 2018; 4 (1)
URL: http://ijca.iums.ac.ir/article-1-125-en.html
URL: http://ijca.iums.ac.ir/article-1-125-en.html
Iran University of Medical Sciences
Abstract: (1553 Views)
Abstract
Background: Convulsion in neonatal period is a considerable clinical issue because of its potential brain damage.One of the benign neonatal seizures known as the fifth day fits ,is due to zinc deficiency. Zinc is a rare element which has spread throughout the body fluids and tissues especially central nervous system. Reduction of neurons’ stimulation has been ascribed as the main effect of zinc on brain. In this study we aimed to determine the cerebrospinal fluid zinc levels of neonates and evaluate its relationship with seizure disorders.
Methods: In this cross sectional study,cerebro-spinal zinc levels was determined in 117 neonates in Ali Asghar children hospital,Tehran,Iran during 2012-2014.Zinc levels was measured using atomic absorption spectrophotometry. Other data about gestational age,birth weight,gender,type of delivery, seizure and underlying diseases at the time of admission was recorded too and analyzed by SPSS soft ware .
Results: Mean cerebro-spinal zinc levels in 117 neonate was 8.96±3.87 µg/dl(between 3.5 and 24.4) and 14.5 % of them were suffered by convulsion.Of all patients, 98.3% had zinc deficiency.There was no significant difference between cerebrospinal zinc levels in two groups with and without seizures. There was no relationship between zinc and gestational age,birth weight,gender and type of delivery and underlying diseases(p>0.05).
Conclusions: According to the results, we found zinc deficiency in CSF of most of our patients without relationship to seizure disorders.It is recommended to evaluate zinc condition in acute ill neonates.
Key words: CSF,Neonate,Seizure,Zinc
Background: Convulsion in neonatal period is a considerable clinical issue because of its potential brain damage.One of the benign neonatal seizures known as the fifth day fits ,is due to zinc deficiency. Zinc is a rare element which has spread throughout the body fluids and tissues especially central nervous system. Reduction of neurons’ stimulation has been ascribed as the main effect of zinc on brain. In this study we aimed to determine the cerebrospinal fluid zinc levels of neonates and evaluate its relationship with seizure disorders.
Methods: In this cross sectional study,cerebro-spinal zinc levels was determined in 117 neonates in Ali Asghar children hospital,Tehran,Iran during 2012-2014.Zinc levels was measured using atomic absorption spectrophotometry. Other data about gestational age,birth weight,gender,type of delivery, seizure and underlying diseases at the time of admission was recorded too and analyzed by SPSS soft ware .
Results: Mean cerebro-spinal zinc levels in 117 neonate was 8.96±3.87 µg/dl(between 3.5 and 24.4) and 14.5 % of them were suffered by convulsion.Of all patients, 98.3% had zinc deficiency.There was no significant difference between cerebrospinal zinc levels in two groups with and without seizures. There was no relationship between zinc and gestational age,birth weight,gender and type of delivery and underlying diseases(p>0.05).
Conclusions: According to the results, we found zinc deficiency in CSF of most of our patients without relationship to seizure disorders.It is recommended to evaluate zinc condition in acute ill neonates.
Key words: CSF,Neonate,Seizure,Zinc
Type of Study: Original Research |
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