Background: Neuroblastoma is the most common extracranial solid tumor in children and the most common malignancy in infant. Some tumors release vasoactive intestinal peptide (VIP), causing a profound secretory diarrhea.
In this report we describe a 33 month old girl with intermittent diarrhea from 9 month ago and hypokalemia resistant to treatment .She had increased VMA in 24hour urin .After complete workup she had a mass in her thorax that resected and her diarrhea and hypokalemia was improved.
Conclusion: In children with resistant diarrhea we should consider tumors secreting VIP.