en مدیریت دیابت کتواسیدوز در کودکان سیستماتیک و متاآنالیز Systematic Review & Metaanalysis Diabetic ketoacidosis (DKA) is one of the leading causes of mortality in diabetic children<span dir="RTL">.</span> This study aimed to determine the frequency of mortality and complications of DKA during treatment in order to make the necessary modifications with regard to the common treatment problems<span dir="RTL">.</span><br> This was a cross sectional study, where patients were selected by examining the records of 112 children under the age of 15 who had been admitted to the pediatric intensive care unit of Ali Asghar Children&#39;s Hospital during 2014-2017 with DKA diagnosis. Required information were extracted from the records. Statistical analysis was performed using Chi-square (&chi;²) test, independent samples T-test and SPSS, Version 16. P value less than 0.05 was consider significant.<br> The mean age of the children was 9.9 &plusmn; 3.15 years. In 66% of the patients, the first manifestation of diabetes was DKA. Regarding the type of serum therapy, hyponatremia was observed in 15%, hypernatremia in 4.6%, hyperkalemia in 4.5%, and hypokalemia in 15.2% of the patients during treatment. The mortality rate was 2.7% (3case). While other complication such as cerebral edema were reported in 20 cases (17.9%). Another important point in our study was that, among the initial markers, several clinical and laboratory markers had a high potential for predicting DKA-related mortality, including the need for intubation&nbsp; at the time of admission, increased inflammatory factors, severe hyperglycemia, evidence of renal dysfunction, hypophosphatemia, and vitamin D deficiency. Also, in predicting cerebral edema, various base markers were identified as predictors that consist of low GCS on admission, tachypnea, increased level of inflammatory factors, increased BUN, severe metabolic acidosis, leukocytosis, thrombocytosis, hypophosphatemia, vitamin D deficiency and increased Hb A1C.<br> &nbsp; Diabetic Ketoacidosis 0 0 http://ijca.iums.ac.ir/browse.php?a_code=A-10-68-2&slc_lang=en&sid=1 Behzad Haghighi Aski بهزاد حقیقی اسکی Haghighi_behzad@yahoo.com 1003194753284600707 1003194753284600707 No Iran university of mdeical sciences دانشگاه علوم پزشکی ایران Ali Manafi Anari علی منافی اناری Amanafi55@yahoo.com 1003194753284600708 1003194753284600708 No Iran university of mdeical sciences دانشگاه علوم پزشکی ایران Nazanin Sarejloo نازنین سارجلو nazaninsarejloo@gmail.com 1003194753284600709 1003194753284600709 Yes Iran university of mdeical sciences دانشگاه علوم پزشکی ایران Farhad Abolhassan Choobdar فرهاد ابوالحسن چوبدار drchoobdar@gmail.com 1003194753284600710 1003194753284600710 No Iran university of mdeical sciences دانشگاه علوم پزشکی ایران Ramin Saemi رامین صائمی raminsaemi@yahoo.com 1003194753284600711 1003194753284600711 No rozita Hoseini رزیتا حسینی rozitahoseini@yahoo.com 1003194753284600712 1003194753284600712 No Iran university of mdeical sciences دانشگاه علوم پزشکی ایران Davod Amirkashani داود امیرکاشانی damirkashani58@gmail.com 1003194753284600713 1003194753284600713 No Iran university of mdeical sciences دانشگاه علوم پزشکی ایران Zahra Serati زهرا صراطی zserati@yahoo.co.uk 1003194753284600714 1003194753284600714 No Shiraz university of mdeical sciences دانشگاه علوم پزشکی شیراز