en گزارش مورد case report <p class="MsoNormal" style="text-indent: 12.6pt"><b><span style="font-size: 10pt color: rgb(23, 54, 93)">Background and Objective</span></b><b><span style="font-size: 10pt">:</span></b><span style="font-size: 10pt"> Vesicoureteral reflux (VUR) is one of the most common urinary tract abnormalities in patients with urinary tract infection. Nowadays noninvasive diagnostic methods are suggested to recognize VUR and its severity. <!--stripped--><!--stripped--></span></p> <p class="MsoNormal" style="text-indent: 12.6pt"><b><span style="font-size: 10pt color: rgb(23, 54, 93)">Methods</span></b><b><span style="font-size: 10pt">:&nbsp;</span></b><span style="font-size: 10pt">We measured urinary and serum fibronectin in 51 children with VUR.<!--stripped--><!--stripped--></span></p> <p class="MsoNormal" style="text-indent: 12.6pt"><b><span style="font-size: 10pt color: rgb(23, 54, 93)">Results</span></b><b><span style="font-size: 10pt">:&nbsp;</span></b><span style="font-size: 10pt">The mean serum fibronectin was 318.3&plusmn;112.1 in children with low grade VUR versus 356.1&plusmn;189.9 in children with high grade VUR (p>0.05). The mean urinary fibronectin was also 31.5&plusmn;12.9 in low grade VUR and 25.9&plusmn;14.2 in high grade VUR (p>0.05). Thus we found no association between the severity of VUR and the amount of fibronectin in serum and urine of patients. We also f found no relationship between dimercaptosuccinic acid (DMSA) changes at the acute phase of unitary tract infection (UTI) and serum and urine fibronectin.<!--stripped--><!--stripped--></span></p> <p><b><span style="font-size: 10pt font-family: 'Times New Roman', serif color: rgb(23, 54, 93)">Conclusion</span><span style="font-size: 10pt font-family: 'Times New Roman', serif">:&nbsp;</span></b><span style="font-size: 10pt font-family: 'Times New Roman', serif">Contrary to some previous studies, we showed the serum and urinary fibronectin cannot preclude the severity and grade of VUR and hence it is not suitable surrogate marker for imaging techniques for VUR diagnosis.</span></p> Vesicoureteral reflux (VUR), Fibronectin, Children, Unitary tract infection (UTI) 10 13 http://ijca.iums.ac.ir/browse.php?a_code=A-10-1-3&slc_lang=en&sid=1 Nahid Rahimzadeh 1003194753284600139 1003194753284600139 No Pediatric Transplantation and Dialysis Research Center Mersedeh Ghodsi 1003194753284600140 1003194753284600140 No Mina Torkzaban 1003194753284600141 1003194753284600141 No LabafI Nejad Hospital