en پژوهشي اصیل Original Research <p><strong>Background and Objective:</strong> Despite consistent evidence that probiotics reduce the duration of diarrhea, there is only weak evidence for their efficacy in reducing the duration of hospitalization. Another source of heteroge-neity for probiotic trials is the type of probiotic being assessed; also, information about combined products is scarce.<br> <strong>Methods:</strong> This is a randomized, single-blind controlled clinical trial performed in children hospitalized with acute rotavirus diarrhea carried out at a university hospital in Tehran, Iran. Children were randomly assigned to receive rehydration therapy or the same plus a multi-strain probiotic preparation. The primary outcome was the duration of hospitalization..<br> <strong>Findings:</strong> A total of 60 patients with acute diarrhea secondary to rotavirus infection were included; baseline characteristics were similar in both groups. A statistically significant difference in the duration of hospitalization was observed (p <0.001) in children receiving probiotic (5.07 &plusmn; 1.30) in comparison to the control group (8.22 &plusmn; 2.14).<br> <strong>Conclusion: </strong>Results of this study support the use of multi-strain preparation probiotics in treating rotavirus acute diarrhea.</p> پروبیوتیک, اسهال حاد, روتا ویروس, کودکان Probiotics, Rotavirus, Diarrhea and Children 5 9 http://ijca.iums.ac.ir/browse.php?a_code=A-10-37-1&slc_lang=en&sid=1 Behnam Sobouti 1003194753284600355 1003194753284600355 No Samileh Noorbakhsh 1003194753284600356 1003194753284600356 No Iran University of Medical Sciences, Tehran, Iran. Haleh Ashraf 1003194753284600357 1003194753284600357 No Tehran University of Medical Sciences, Tehran, Iran Shaghayegh Ashraf -Talesh ha_as_ta@yahoo.com 1003194753284600358 1003194753284600358 Yes Resident of pediatrics