fa دیگر Other پژوهشي اصیل Original Research <p>Background and Objective: To assess the effectiveness and safety of oral amiloride for the treatment of<br> edema in pediatric patients with idiopathic nephrotic syndrome.<br> Methods: A randomized trial of amiloride vs hydrochlorthiazide was done in 34 patients. The mean age was<br> 4.3&plusmn;0.7 years old. After a 2 week washout of diuretic therapy, nephrotic children with edema were randomized<br> into two groups receiving amiloride vs hydrochlorthiazide. The effect of diuretics was assessed by the amount of<br> weight reduction and the measurement of urinary fractional excretion of sodium during the first three days of<br> diuretic therapy. The primary end point was the decrease in body weight.<br> Findings: Of 34 patients enrolled for this trial, 17 patients were in amiloride group and 17 patients in hydrochlorthiazide<br> group. The mean weight loss during the first three days of diuretic therapy was 1.3&plusmn;0.65 kg in<br> amiloride group and 1.19&plusmn;0.4 kg in hydrochlorthiazide group (PV=0.55). The mean of maximum urinary fractional<br> excretion of sodium during the first three days of diuretic therapy was 2.1&plusmn;0.65% in amiloride group and<br> 1.8&plusmn;1% in hydrochlorthiazide group.<br> Conclusion: There was not any difference between amiloride and hydrochlorthiazide medications in reducing<br> weight and increasing urinary fractional excretion of sodium in children with nephrotic syndrome.</p> Amiloride, hydrochlorthiazide, Children, Nephrotic syndrome 29 31 http://ijca.iums.ac.ir/browse.php?a_code=A-10-1-46&slc_lang=fa&sid=1 Soheila Mahdavinia 1003194753284600320 1003194753284600320 No Iran University of Medical Sciences, Tehran, Iran Hasan Otukesh 1003194753284600321 1003194753284600321 No Iran University of Medical Sciences, Tehran, Iran Rozita Hoseini rozitahoseini@yahoo.com 1003194753284600322 1003194753284600322 Yes Iran University of Medical Sciences, Tehran, Iran Mehrdad Shheikhvatan 1003194753284600323 1003194753284600323 No Iran University of Medical Sciences, Tehran, Iran