fa پژوهشي اصیل Original Research <p><strong>Background and Objective:</strong> Hemolytic Uremic Syndrome (HUS) is a thrombotic microangiopathy that&nbsp;contains hemolytic anemia, thrombocytopenia, renal failure and other organ involvement including central&nbsp;nervous system. Frequency of neurologic complications in patients with HUS is high and important cause of&nbsp;mortality. This study was performed to determine seizure disorders in term of acute neurologic complications in<br> children with HUS.<br> <strong>Methods:</strong> In this descriptive, cross sectional study, 46 children with diagnosis of HUS were admitted to the&nbsp;Nephrology ward of Ali-Asghar Children&rsquo;s Hospital from 2010 to 2015. They were evaluated about age, sex,&nbsp;neurologic complications including seizure, diarrhea, PICU admission and mortality rate.<br> <strong>Results:</strong> In this Study,46 patients were enrolled. Twenty-five (54.3%) patients were male. Mean age was&nbsp;4.65&plusmn;4.2 (range from 4month to 15 year). Acute neurologic complications were seen in 16(34.8%) of patients&nbsp;including seizures in 8(17.5%) of cases. Diarrhea was seen in 21(46%) of cases and 18(39%) of patients admitted&nbsp;in PICU. Four (9%) cases died and two of them had seizures. There was no relationship between seizure<br> disorders and age, sex, diarrhea and mortality rate. There was a significant association between mortality and&nbsp;age (p value =0.049, CI=95%, lower = -8.60, upper= -0.02) and between mortality and PICU admission&nbsp;(p=0.009).<br> <strong>Conclusion: </strong>In children with HUS neurologic complications such as seizure is common. Mortality rate is&nbsp;higher in younger patients specially with early admission in PICU.</p> Child, HUS, Mortality, Seizure 1 4 http://ijca.iums.ac.ir/browse.php?a_code=A-10-1-47&slc_lang=fa&sid=1