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Volume 3, Issue 4 (11-2017)
IJCA 2017, 3(4): 13-18 |
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Naghshidaian R, Nasiri Kalmarzi R, Eskandarifar A, Khalafi B, Fotoohi A, Noshadi S et al . Comparing serum levels of interleukin-6 (IL-6) in acute pyelonephritis versus acute cystitis in 6 months to 12 years old children. IJCA 2017; 3 (4) :13-18
URL: http://ijca.iums.ac.ir/article-1-113-en.html
URL: http://ijca.iums.ac.ir/article-1-113-en.html
Rama Naghshidaian 
, Rasoul Nasiri Kalmarzi 
, Alireza Eskandarifar , Behzad Khalafi , Ahmad Fotoohi , Soroush Noshadi , Hedayat Rasouli
, Rasoul Nasiri Kalmarzi , Alireza Eskandarifar , Behzad Khalafi , Ahmad Fotoohi , Soroush Noshadi , Hedayat Rasouli
urdistan University of Medical Sciences, Sanandaj, Iran
Abstract: (2109 Views)
Background and Objectives: Urinary Tract Infections (UTI) is a common disorder in pediatrics and early diagnosis is important. However, in young children diagnosis is problematic. A problem is variety in sign and symptoms and for exact diagnosis in some case we need expensive modalities. Thus, new way is needed. IL-6 at last decades was preferred to UTI diagnosis and upper/lower involvement differentiation. According to contrariety in IL-6 accuracy this study was performed to learn about diagnostic accuracy of plasma IL-6 in UTI diagnosis and its power for differentiating upper from lower involvement.
Methods: At this descriptive study, 83 patients were included and examined for Interleukin 6 value in both urinary tract diagnosis and upper/lower involvement differentiation. Demographic characteristic like age, gender, history, physical examination beside of blood tests like white blood cell count, ESR, CRP, IL-6 were done and results listed. Descriptive parameters were reported by mean and frequency and for statistical analysis was performed using t-test in SPSS v.16. ROC curve was checked for diagnosed value.
Results: In this study 83 patients (14 control group, 33(39.8%) cystitis, 36(43.4%) pyelonephritis) with 3.93±3.069 mean age enrolled. Age distribution at this study was 20, 63 for males and females, respectively. The IL-6 level in cystitis was higher than control and but was not significant. In ROC curve sensitivity and specify of IL-6 for cystitis were 52%, 50% and for pyelonephritis 60%, 50%, respectively.
Conclusion: According to this study, IL-6 is not a good biomarker for Urinary tract infection and differentiation upper tract involvement from the lower tract. A wide range of Il-6 level and useless of this biomarker can be due to gender distribution, time of disease presence, bacterial virulence and other factors. Therefore, studies on large sample is recommended.
Methods: At this descriptive study, 83 patients were included and examined for Interleukin 6 value in both urinary tract diagnosis and upper/lower involvement differentiation. Demographic characteristic like age, gender, history, physical examination beside of blood tests like white blood cell count, ESR, CRP, IL-6 were done and results listed. Descriptive parameters were reported by mean and frequency and for statistical analysis was performed using t-test in SPSS v.16. ROC curve was checked for diagnosed value.
Results: In this study 83 patients (14 control group, 33(39.8%) cystitis, 36(43.4%) pyelonephritis) with 3.93±3.069 mean age enrolled. Age distribution at this study was 20, 63 for males and females, respectively. The IL-6 level in cystitis was higher than control and but was not significant. In ROC curve sensitivity and specify of IL-6 for cystitis were 52%, 50% and for pyelonephritis 60%, 50%, respectively.
Conclusion: According to this study, IL-6 is not a good biomarker for Urinary tract infection and differentiation upper tract involvement from the lower tract. A wide range of Il-6 level and useless of this biomarker can be due to gender distribution, time of disease presence, bacterial virulence and other factors. Therefore, studies on large sample is recommended.
Type of Study: Original Research |
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