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Volume 3, Issue 4 (11-2017)
IJCA 2017, 3(4): 0-0 |
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Bahrami A, Sayyahfar S, Bahoush G, Shetaban M, Vafapour M, Torabi S. Leukocyte adhesion deficiency and Cardiac Arrhythmia. IJCA 2017; 3 (4)
URL: http://ijca.iums.ac.ir/article-1-124-en.html
URL: http://ijca.iums.ac.ir/article-1-124-en.html
Ahmad Bahrami 
, Shirin Sayyahfar , Gholareza Bahoush , Mojtaba Shetaban , Mryam Vafapour , Sara Torabi
, Shirin Sayyahfar , Gholareza Bahoush , Mojtaba Shetaban , Mryam Vafapour , Sara Torabi
Iran university of mdeical sciences
Abstract: (2021 Views)
Leukocyte adhesion deficiency (LAD) is a rare inherited primary immunodeficiency disorder characterized by the presence of a defect of phagocytic function resulting from a lack of leukocyte cell surface expression of β₂ integrin molecules (CD11 and CD18) that are essential for leukocyte adhesion to endothelial cells and chemotaxis. It is characterized by delayed separation of the umbilical cord, recurrent bacterial and fungal infections, defective wound healing, blood neutrophilia and a high mortality rate at an early age. Here, we report a case of LAD in a 38 days old male with recurrent hospitalizations because of severe pneumonia and positive bacterial cultures is presented. His medical history included neonatal sepsis and delayed umbilical cord detachment. Laboratory studies showed marked leukocytosis with predominance of neutrophils and decreased CD11b and CD18.
Type of Study: case report |
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