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Volume 1, Issue 1 (5-2015)
IJCA 2015, 1(1): 10-13 |
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Rahimzadeh N, Ghodsi M, Torkzaban M. Fibronectin in reflux nephropathy Is it a marker of reflux grade?. IJCA 2015; 1 (1) :10-13
URL: http://ijca.iums.ac.ir/article-1-23-en.html
URL: http://ijca.iums.ac.ir/article-1-23-en.html
Abstract: (3480 Views)
Background and Objective: Vesicoureteral reflux (VUR) is one of the most common urinary tract abnormalities in patients with urinary tract infection. Nowadays noninvasive diagnostic methods are suggested to recognize VUR and its severity.
Methods: We measured urinary and serum fibronectin in 51 children with VUR.
Results: The mean serum fibronectin was 318.3±112.1 in children with low grade VUR versus 356.1±189.9 in children with high grade VUR (p>0.05). The mean urinary fibronectin was also 31.5±12.9 in low grade VUR and 25.9±14.2 in high grade VUR (p>0.05). Thus we found no association between the severity of VUR and the amount of fibronectin in serum and urine of patients. We also f found no relationship between dimercaptosuccinic acid (DMSA) changes at the acute phase of unitary tract infection (UTI) and serum and urine fibronectin.
Conclusion: Contrary to some previous studies, we showed the serum and urinary fibronectin cannot preclude the severity and grade of VUR and hence it is not suitable surrogate marker for imaging techniques for VUR diagnosis.
Type of Study: case report |
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